Ten-year natural history of visual function in Japanese patients with Leber hereditary optic neuropathy: A retrospective cohort study
Fig 3
Time to attainment of visual acuity thresholds: Kaplan–Meier survival curves (proportion of non-achievement).
The curves show the proportion of the survival function: cumulative achievement = 1 − survival. The x-axis represents the number of months since the onset (0 = time of subjective awareness of vision loss). The eyes that met the threshold at baseline were excluded from the risk set. The shaded bands denote 95% confidence intervals. The groups included the overall cohort and subgroups (see Methods for definitions). (A) Time to best-corrected visual acuity (BCVA) ≤1.6 logMAR, overall cohort (n = 42 eyes). (B) Time to BCVA ≤1.6 logMAR, subgroup (n = 35 eyes). (C) Time to BCVA ≤1.3 logMAR, overall cohort (n = 49 eyes). (D) Time to BCVA ≤1.3 logMAR, subgroup (n = 39 eyes). Note: In all curves, the survival function did not drop below 0.5; therefore, the median time to attainment (50%) could not be calculated (not reached). Curves depict time to first attainment; eyes at threshold at baseline were excluded.