Ten-year natural history of visual function in Japanese patients with Leber hereditary optic neuropathy: A retrospective cohort study
Fig 2
Ten-year trajectories of BCVA (logMAR) visualized with LOWESS (descriptive only).
A, overall cohort; B, predefined subgroup (≥15 years with the m.11778G > A mutation). Solid lines show LOWESS curves and shaded areas indicate 95% CIs. Vertical dashed lines mark 12 and 60 months (boundaries for Chronic and Late Chronic phases). This figure is descriptive; confirmatory inference is based on piecewise LMMs (Table 3). Lower logMAR indicates better vision.