Poldip2 deficiency attenuates lung disease severity in a mouse model of COVID-19
Fig 4
Poldip2 depletion alleviates lung tissue alterations induced by SARS-CoV-2 infection.
Male and female hACE2/Poldip2 mice were euthanized 7 days after intranasal administration of PBS or SARS-CoV-2. Lungs were processed for histology and paraffin sections were stained with hematoxylin/eosin. (A) SARS-CoV-2 infection increased tissue damage and alveolar wall thickness compared to PBS in Poldip2+/+ (top), but not in Poldip2+/- mice (bottom). (B) Septal thickness was quantified as described in Methods. Bars represent means ± SEM from n = 5-6 mice. Data were analyzed by 2-way ANOVA: ns, not significant, #P = 0.075, *P < 0.05, **P < 0.01.