Poldip2 deficiency attenuates lung disease severity in a mouse model of COVID-19
Fig 2
Acute infection does not significantly reduce body weights and temperatures.
Male and female human ACE2 transgenic, Poldip2+/+ or Poldip2+/- (hACE2/Poldip2) mice received a single intranasal inoculation of PBS or SARS-CoV-2 on day zero. Body temperatures (A, B) and weights (C, D) were measured every other day. Time courses (A, C) show relative values, calculated by dividing measurements for each mouse by its own initial value (day zero) and multiplied by 100 for weights. The graphs represent means ± SEM of data from n = 8-21 animals. Body temperatures at day 6 (B) and weight changes between day 6 and day zero (D), were analyzed by 2-way ANOVA: ns, not significant. On day zero, average body temperatures were identical between males and females, across all groups (35 ± 0.1°C) and average body weights were higher by a few grams in males (M) than females (F): M 29.4 ± 0.7, F 21.6 ± 0.4 in Poldip2 + /+ and M 25.9 ± 0.5, F 21.4 ± 0.3 in Poldip2 + /- (errors indicate SEM).