Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators
Fig 5
Effects of calcitriol on hepatic MMP-12, TIMP-1, α-SMA, and TGF-β1 protein expression in DEN-induced liver fibrosis.
Representative western blot images and quantitative analyses for MMP-12 (A), TIMP-1 (B), α-SMA (C), and TGF-β1 (D). DEN significantly increased MMP-12, α-SMA, and TGF-β1 compared with CON, while calcitriol reduced their expression. TIMP-1 showed no significant changes across groups. Data are presented as mean ± SD, *p < 0.05 when compared with the CON group, #p < 0.05 when compared with the DEN group.