Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators
Fig 4
Effects of calcitriol on hepatic NF-κB p65 expression in DEN-induced liver fibrosis.
(A) Representative immunohistochemistry images of NF-κB p65 expression. Brown staining indicates positive expression (images shown at 10x magnification). (B) Quantification of strongly positive NF-κB p65 staining (% of total pixels). DEN markedly increased NF-kB p65 expression compared with CON, while both low- and high-dose calcitriol reduced NF-kB p65. Data are presented as mean ± SD, n = 6/group. *p < 0.05 when compared with the CON group, #p < 0.05 when compared with the DEN group.