Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators
Fig 2
Effects of calcitriol on serum ALT, AST, and hepatic MDA levels in DEN-induced liver fibrosis.
(A) ALT, (B) AST, and (C) hepatic MDA levels in the CON, DEN, DEN + LVD₃, and DEN + HVD₃ group after 8 weeks. DEN significantly increased ALT, AST, and MDA levels. Calcitriol attenuated ALT and AST similarly at both low and high doses, while the high dose produced a greater reduction in MDA than the low dose. Data are presented as mean ± SD, n = 6/group. *p < 0.05 when compared with the CON group, #p < 0.05 when compared with the DEN group, &p < 0.05 when compared with the DEN + LVD3.