Unraveling the role of ChREBP in lung adenocarcinoma: Expression, regulatory networks, and potential functional impact
Fig 6
Prognostic significance of ChREBP and its associated genes in LUAD.
Kaplan–Meier plot demonstrates the median overall survival (OS) of LUAD patients. Only genes with statistical significance (p < 0.05) and a false discovery rate (FDR) of 1% are shown. (A) ChREBP-α (MLXIPL). (B-E) Top 10 downregulated genes by dnChREBP in NCI-H1975 cells: KLHL4 (B), SHROOM4 (C), TMEM47 D) and ARMCX2B (E). (F-J) Top 10 upregulated genes by dnChREBP in NCI-H1975 cells: IRX2 (F), CD99P1 (G), PELI2 (H), NFASC (I), and TFPT (J). (K-O) Hub genes: SPP1 (K), PECAM1 (L), FLG (M), CCN2 (N), IL1A (O).