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A single dose of purified human antibody from transchromosomic bovines mitigates aerosolized Venezuelan equine encephalitis virus disease in cynomolgus macaques

Fig 2

Febrile responses for cohort 1.

Actual (red lines) and forecasted (black lines) temperature telemetry data from cohort 1 cynomolgus macaques challenged with VEEV TrD and either treated with control liquid TcpAb (row A) or treated with liquid anti-VEEV TcpAb 24 hours prior to infection (Pre) or 24 hours after infection (Post). Shaded areas represent the first and second febrile phases determined a previous study [28]. Forecast temperatures are calculated with NCSS-PASS Software based upon the at least 3 days of data recorded prior to challenge. The number above each temperature profile corresponds to the unique identification number of the macaque.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0347864.g002