Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation
Fig 10
Molecular docking analysis of the binding between TSA and 7 core AD target proteins performed via CB-Dock2 (AutoDock Vina v1.1.2).
(A-G). Molecular docking conformation diagrams of complexes formed by TSA binding to MET, GRIA2, GABRB2, GABARAPL1, EGR1, EFNA1 and CDK5 proteins, respectively. Receptor: ribbon model; TSA: stick model; yellow dashed lines: hydrogen bonds.