Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation
Fig 7
Pathway Enrichment Analysis of Core Genes and Regulatory Network Construction.
(A). GSEA enrichment plot of core genes, highlighting top AD-related significant pathways. (B). ceRNA regulatory network centered on 8 core genes (48 lncRNAs, 51 miRNAs; light green = lncRNAs, green = miRNAs, orange = core mRNAs). (C). Bar chart of NES of significantly enriched TF motifs (RcisTarget, NES > 3.5). (D). TF motif gene recovery curve, verifying the enrichment reliability of core target genes.