Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation
Fig 3
Functional Annotation of 60 TSA-associated Key Genes for AD and PPI Network Analysis.
(A-C). GO, KEGG, and DO enrichment bubble plots (significance threshold: P < 0.05, adjusted q < 0.05). (D). PPI network constructed based on the STRING database (confidence threshold was set at 0.4). (E). Key nodes of the PPI network identified by the cytoHubba plugin. (F). Key PPI nodes identified by CytoNCA plugin; red = upregulated genes in AD, blue = downregulated genes in AD. (G). Venn diagram of the intersection of screening results from cytoHubba and CytoNCA (a total of 14 candidate core genes were obtained).