Evaluation of AT121 versus morphine on cortical neurons electrophysiology and dopamine concentrations in hippocampal cells
Fig 10
Modulation of action potential amplitude and membrane current in pyramidal cells from newborn mice cerebral cortex by morphine, AT121, and naloxone (10μg/ml).
Measurements were taken 5 minutes after addition (n = 7 × 8 cells). Signals were recorded in voltage-clamp mode at -60mV holding, with current measurements expressed in 0pA; While holding potential at 0mV in VC mode gives a + 10pA.