Evaluation of AT121 versus morphine on cortical neurons electrophysiology and dopamine concentrations in hippocampal cells
Fig 9
Modulation of action potential amplitude and membrane current in pyramidal cells from newborn mice cerebral cortex by morphine, AT121, and acetylcholine (10μg/ml).
Measurements were taken 5 minutes after addition culture medium exposure (n = 7 × 8 cells). Signals were recorded in voltage-clamp mode at -60mV holding, with current measurements expressed in 0pA; While holding potential at 0mV in VC mode gives a + 10pA.