Beyond individual markers: Prognostic value of the combined CEA/PNI score in metastatic colorectal cancer as a predictor of survival
Fig 2
Overall survival according to the combined CEA/PNI score at first response assessment.
Kaplan–Meier survival curves for overall survival (OS) stratified by the combined carcinoembryonic antigen (CEA) and prognostic nutritional index (PNI) score at the first response assessment (2 months after initiation of systemic therapy). Patients were classified into four groups: CEAHIGH & PNILOW, CEAHIGH & PNIHIGH, CEALOW & PNILOW, and CEALOW & PNIHIGH. The high-risk group (CEAHIGH & PNILOW) showed significantly worse OS compared to the reference group (CEALOW & PNIHIGH), with a hazard ratio (HR) of 2.30 (95% confidence interval [CI]: 1.27–4.18; p = 0.006). Survival distributions were compared using the log-rank test.