Serum proteomic changes in atopic dermatitis patients treated with cyclosporine
Fig 2
Proteomic changes after 2 and 4 weeks of CsA treatment.
(A) Heatmap of differentially expressed proteins (DEPs) (fold change>1.5, p < 0.05, q < 0.05) after 2 weeks of CsA treatment, with markers grouped by unsupervised hierarchical clustering based on the 14 DEPs. Yellow color denotes higher and blue color denotes lower mean expression levels. (B) Volcano plot of DEPs after 2 weeks of treatment, the x-axis represents the value of log2-FC and the y-axis represents the mean value of –log10 (p-value). (C) Heatmap of DEPs (fold change>1.5, p < 0.05, q < 0.05) after 4 weeks of CsA treatment, with markers grouped by unsupervised hierarchical clustering based on the 21 DEPs. (D) Volcano plot of DEPs after 4 weeks of treatment, the x-axis represents the value of log2 fold change and the y-axis represents the –log10 (p-value).