Plasma gelsolin as a potential biomarker for intrauterine inflammation in pregnant women with preterm premature rupture of membranes: A pilot study
Fig 2
Temporal changes in WBC, CRP, and pGSN levels in a patients with pPROM.
(A) Plasma gelsolin (pGSN) levels at the time of membrane rupture (day −2 to day 0) in cases of preterm premature rupture of membranes (pPROM), compared with levels in pregnant women without membrane rupture (Non-ROM) during the second trimester (25–33 weeks of gestation). No statistically significant difference in pGSN levels was observed between the two groups (p = 0.16). (B) Comparison of WBC, CRP, and pGSN levels at the time of membrane rupture (ROM; day −2 to day 0) and at delivery (0–7 days before delivery) in patients with pPROM. pGSN levels were significantly lower at delivery compared to the time of membrane rupture. (C) Correlation between the rate of pGSN decline and the interval from ROM to delivery (Spearman’s ρ = 0.84, p = 0.009). WBC, white blood cell; CRP, C-reactive protein; ROM, rupture of membrane.