Quantitative profiling of lifespan-dependent cell-cell communication potential reveals dynamic ligand-receptor network shifts across mouse tissues
Fig 9
Organ-level molecule analysis of the kidney.
(A): high-frequency ligand-receptor pairs, x-axis: time points with different categories of changes, y-axis: ligand (left) to receptor (right), colours show categories of changes, and the size of the dot indicates the frequency of changes in the organ (the number of types of communication for each particular pair). Most changes of pair within a single time point did not possess more than one categorical change. The pairs shown here are a subset of the top 20 pairs (see methods) for ease of visualisation, with all shown in Fig 7 in S1 Fig. (B): high-frequency single molecule patterns for the top 20 single molecules selected based on the frequency within each time point on each categorical change. The single molecules shown here are a subset of top 20 single molecules (see methods), with all the top 20 single molecules in Fig 8 in S1 Fig.