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Stirred tank bioreactor process for chikungunya vaccine candidate VEEV-ΔC-CHIKV

Fig 3

Investigation of different cell density conditions.

(A) Glucose consumption. (B) Glutamine consumption. (C) Lactate concentration in the bioreactor. (D) Glucose concentration in the bioreactor. (E) Glutamine concentration in the bioreacor. (F) Glutamate concentration in the bioreactor. (G) Viable cell density in the bioreactor. (H) Virus titer at two cell densities. (I) Total virus concentration obtained at the two cell densities. Glucose, Glc; Glutamine, Gln; Glutamate, Glu; Lactate, Lac.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0344564.g003