Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data
Fig 5
(a) Protein interaction network. The nodes represent the candidate genes, and the color of the nodes from red to yellow represents the degree of the node, which is the number of interactions between each gene and other genes. The redder the color, the more interactions the gene has and the higher the metric value. The size of the node also represents its degree. The larger the size, the more frequent the interaction between the gene and the larger the degree. (b) The important modules selected by MCODE and the hub genes obtained from MCC algorithm. (c) The expression of hub genes in the training set. The box plot indicates the differential expression of key genes in the training set, with red representing the SSc group and blue representing the normal group. P < 0.05 is considered statistically significant. (d) The expression of hub genes in the validation set.