Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients
Fig 5
Identification and analysis of key biomarkers, functional traits, and their abundance changes across patient subgroups.
Panel A, C are combination plots of biomarker abundance changes between groups as determined by the wilcox rank-sum test. The left bar graphs show the average abundance of identified key species in the study groups, with the X-axis representing the average proportion and the Y-axis listing different bacterial genera. Red squares represent Group ST, and blue squares represent Group LT. The right scatter plots show the abundance changes of key species between groups, with the X-axis displaying the difference in average proportions. The numeric value on the far right is the P-value obtained from the Wilcox rank-sum test between species groups. Panel B shows the key species in different blood drug concentration groups, with the left dot plot displaying the identified Biomarkers and their importance to the grouping, retaining results with importance higher than 1.5. The right heatmap uses a color gradient to show the abundance of Biomarkers in the study samples, with redder colors indicating higher abundance, and gray representing the absence of the Biomarker in the sample. Panel D, F list multiple features on the left, related to the duration of medication. Each feature has different red shaded areas in each group, indicating the relative importance of the feature in these two classifiers. The darker the color, the higher the importance of the feature in the classifier. Panel E is a combination plot of key functional abundance changes between groups as determined by the Wilcox rank-sum test. The left chart shows the average proportion for each process, with red representing Group ST and blue representing Group LT. The right chart shows the average difference and 95% confidence intervals for these processes between the two groups.