Annotation-free prediction of immunotherapy response in melanoma using single-cell transcriptomic data
Fig 5
CCR7 and MTRNR2L2 expression according to the melanoma subtypes.
(A, B) CCR7 and MTRNR2L2 expression showed prognostic significance for overall survival, independent of the primary site (A) and histological subtype of melanoma (B). (C) Prognostic differences according to molecular subtypes, including microphthalmia-associated transcription factor (MITF)-low, immune, and keratin subtypes (log-rank test). (D) CCR7 expression patterns across molecular subtypes (Kruskal–Wallis test). (E) Multivariate Cox regression analysis of CCR7 expression in relation to molecular subtype. ALM, acral lentiginous melanoma; LMM, lentigo malignant melanoma; NM, nodular melanoma; SSM, superficial spreading melanoma. (F) Gene expression patterns across mutational subtypes (Kruskal–Wallis test).