Annotation-free prediction of immunotherapy response in melanoma using single-cell transcriptomic data
Fig 4
Clinical significance of CCR7 and MTRNR2L2 across three independent melanoma cohorts with bulk RNA-seq data.
Box plots displaying the expression of genes (CCR7 and MTRNR2L2) in three independent bulk RNA-seq data from melanoma patients with CR/PR (complete response/partial response) and PD/SD (progressive disease/stable disease). Kaplan–Meier survival curves demonstrating associations of genes with overall survival (OS) and progression-free survival (PFS) (log-rank test). Hazard ratio (HR) and 95% confidence intervals from the univariate Cox regression analysis. High CCR7 expression is associated with improved survival, whereas high MTRNR2L2 expression is associated with worse prognosis.