High burden and genetic diversity of β-lactamase-producing Escherichia coli and Klebsiella pneumoniae causing community-acquired urinary tract infections in Southeastern Gabon
Fig 2
Distribution of β-lactamase-encoding genes in E. coli and K. pneumoniae.
This figure illustrates the distribution of beta-lactamase gene combinations identified in E. coli and K. pneumoniae isolates. A total of 35 E. coli and 33 K. pneumoniae isolates producing Extended-Spectrum β-lactamase (ESBL) were analyzed. In E. coli, the most frequent gene combinations included bla-CTX-M-gp1 alone or associated with bla-TEM, whereas in K. pneumoniae, profiles combining bla-SHV, bla-CTX-M-gp1, and bla-TEM were predominant. Carbapenemase genes were investigated in K. pneumoniae and the bla-OXA-48 gene was detected in one isolate. AmpC β-lactamase genes were assessed in 14 K. pneumoniae isolates, in which bla-CMY-2 and bla-ACT-1 were identified, while no AmpC genes were detected in E. coli. Some isolates showed no β-lactamase gene detected by the panel used.