Near Neutral Selectionist Theories (NNST) for SARS-CoV-2 suggested by the substitution-mutation ratio (c/µ) analysis
Fig 2
The varying presence of the molecular clock feature in SARS-CoV-2 genomic segments.
The total percent nucleotide substitution variation (c) for segments exhibiting strict molecular clock (A) or no strict molecular clock (B) over evolution time, averaged over the three SARS-CoV-2 datasets. The time-based substitution rate for Orf1ab 5’UTR obtained from its timeline and coefficient of determination (R2 = 0.9392) was defined as the fundamental genomic mutation rate (µ = c of Orf1ab 5’UTR). See Figures of S6 and S8 Figs for the individual timelines of segments not exhibiting strict molecular clock and Figures of S7 and S9 Figs for the individual timelines of segments exhibiting strict molecular clock.