Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways
Fig 6
Effect of gastrin on H9C2 cardiomyocyte hypertrophy.
(A)Rhodamine-phalloidin staining of F-actin(400×), DAPI stainded nuclei; (B) Quantificantion analysis of cardiomyocyte surface areas; (C-D) RT-PCR analysis for ANP and BNP mRNA in control, gastrin, ISO, and ISO+gastrin groups; (E-F) RT-PCR analysis for ANP and BNP mRNA in control, ISO, ISO+gastrin, and ISO+gastrin+ CI-988 groups;*P < 0.05, **P < 0.01,***P < 0.001, ****P < 0.0001. The data are presented as the mean±SEM. One-way ANOVA with Tukey’s post-hoc was conducted for (Panel B). Welch’s one-wayANOVA analysis was performed of (Panle C-F).