Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways
Fig 2
Effects of gastrin on ISO-induced myocardial hypertrophy in vivo.
(A)Heart weight/Body weight(HW/BW) of five groups; (B)Heart weight/Tibial length(HW/TL) of five groups;(C)Posterior wall of left ventricle(LVPWs) of five groups; (D) Cardiomyocyte cross-sectional areas of five groups; n = 7.(E)Histological cross-sectional image of cardiomyocytes stained with hematoxylin and eosin (H&E);(F)(G)(H)Expression of ANP, BNP, and β-MHC in the hearts of mice across Control, Gastrin, ISO, and ISO+Gastrin groups；(I)(J)(K)Expression of ANP, BNP, and β-MHC in the hearts of mice across Control, ISO, ISO+Gastrin and ISO+Gastrin+CI-988 groups.*P < 0.05,** < 0.01,***P < 0.001, ****P < 0.0001. The data are presented as the mean±SEM. One-way ANOVA with Tukey’s post-hoc was conducted for (Panel A,C,D). Welch’s one-way ANOVA analysis was performed of (Panel B,F-K).