Beyond the transcript: Chromatin implications in trans-splicing in Trypanosomatids
Fig 5
Chromatin organization at TASs in single and multi-copy gene families.
(A) Average histone H3 occupancy (top panel) and heatmaps (bottom panels) in a 1 kb window relative to the TAS for single (green) and multi-copy genes (blue) using T. cruzi histone H3 IP (SRR14691958). Red: High histone H3 density; blue: low histone H3 density. (B) Average FAIRE-seq signals were represented relative to the TAS in a 1 kb window for single (green) and multi-copy genes (blue) of T. cruzi using public data (SRR15902298) (left) and (SRR15902297) (right), respectively. (C) Average dinucleotide frequency for AA/TT/AT/TA (purple), CG/CC/GC/CG (orange) and other possible combinations (light blue) in a 100 bp window relative to the TAS for single and multi-copy genes.