The JAK1-STAT1 signaling pathway triggers inflammation responses in chronic obstructive sleep apnea rat model
Fig 2
Activation of JAK1-STAT1 signaling in lung tissues after CIH.
(A-B) Western blot analysis showing phosphorylated JAK1 protein expression (representative bands and quantitative data). (C-D) Western blot analysis showing phosphorylated STAT1 (Tyr701) levels (representative bands and quantitative data). (E-F) Immunohistochemical staining and quantification of p-JAK1-positive cells. (G-H) p-STAT1 immunostaining and positive cell counting. Data expressed as mean ± SEM (n = 8 rats/group). *p < 0.05, **p < 0.01 vs Sham group (unpaired t-test). Scale bars: 20 μm. Arrows indicate nuclear localization of target proteins in CIH group.