Distinct DNA methylation signatures in maternal blood reveal unique immune cell shifts in preeclampsia and the pregnancy-postpartum transition
Fig 5
Immune cell composition across gestational age within GSE192918.
Houseman (2012) was used to deconvolute both GEO sets to identify changes in the proportion of monocytes, granulocytes, natural killer cells, B-cells, CD4 + T cells and CD8 + T cells across ‘first trimester, ‘second trimester’, ‘third trimester’ and ‘postpartum’. GSE192918 defined these stages as follows: early-pregnancy (10-14 weeks), mid-pregnancy (24-28 weeks), at delivery (38-40 weeks), and postpartum (10 month post-delivery). All data are presented is mean ± SEM. A linear model was conducted for each cell type. An FDR-adjusted p-value of ≤ 0.05 was considered statistically significant.