Distinct DNA methylation signatures in maternal blood reveal unique immune cell shifts in preeclampsia and the pregnancy-postpartum transition
Fig 3
Average Estimated Cell Type Distribution across gestation for (A) GSE37722 and (B) GSE192918.
Houseman (2012) was used to deconvolute both GEO sets to identify changes in the proportion of monocytes, granulocytes, natural killer cells, B-cells, CD4 + T cells and CD8 + T cells across ‘first trimester, ‘second trimester’, ‘third trimester’ or ‘at delivery’ and ‘postpartum’. While GSE37722 included data for normotensive pregnancy stages, the exact timings of these stages were not explicitly defined in the GEO database. Differences in distribution across gestational were assessed using an Anderson-Darling all pairs comparison test. A p-value of ≤ 0.05 was considered statistically significant.