Distinct DNA methylation signatures in maternal blood reveal unique immune cell shifts in preeclampsia and the pregnancy-postpartum transition
Fig 2
(A) Average Estimated Cell Type Distribution and (B) Immune cell proportion between normotensive (grey, control) and preeclamptic (white) pregnancies.
Houseman (2012) was used to deconvolute GSE37722 (N = 14 control, N = 14 preeclamptic pregnancies) to identify changes in the proportion of monocytes, granulocytes, natural killer cells, B-cells, CD4 + T cells and CD8 + T cells. All data is presented as mean. A Kolmogorov-Smirnoff test was used to assess differences in the overall distributions, while a Wilcoxon test was conducted for each cell type. A p-value of ≤ 0.05 was considered statistically significant.