Chronic intestinal immune activation reveals separable impacts of inflammation and barrier loss on hallmarks of ageing
Fig 6
Both Relish and JNK activation drive early mortality and intestinal barrier loss.
(A – D) Lifespan curves (A & C) and Smurf proportions (B & D) for TiGS > UAS-RelVP16 (A & B) and TiGS > UAS-hepCA (C & D) female flies drug induced (RU25 or 50) from early adulthood and uninduced controls (RU0). n > 200 flies/condition, NS = non-Smurf, SMF = Smurf. Log rank test was used for survival data and binomial test for Smurf proportions. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.