Molecular and immunological heterogeneity of eosinophilic esophagitis: Insights and subtyping
Fig 5
Hub gene identification from selected gene modules using CytoScape plugin CytoHubba degree centrality algorithm and filtering to top 10 by degree.
(A): Hub gene signature for the MElightgreen module, shows key genes such as IL13, NTRK1, BDNF and IGF1R play a significant role in the pathophysiology of conventional EoE. (B): Hub gene signature for the MElightsteelblue1 module, shows important genes like STAT1, CXCL10, CXCL8 play major roles in the pathophysiology of lymphocytic esophagitis. (C) Hub gene signature for MEwhite module includes key genes such as CDK1, CCNB1, CENPA, RAD51 and CDC20 which are involved in cell proliferation epithelial turnover. This module shows positive correlation with conventional EoE and a negative correlation with EoE-like esophagitis.