Anticonvulsant effects of novel and repurposed drugs on docetaxel-induced neuropathy in C. elegans
Fig 2
Nematodes treated with chronic docetaxel, display an increase in time to recovery from shock-induced seizure-like behaviors when compared to nematodes exposed to M9 saline alone.
(A) Chronic exposure to docetaxel increases time to recovery with increasing concentrations. Different letters denote a statistically significant difference in the mean values between the groups where “a” stands for not statistically significantly different from M9 saline, “b” stands for statistically significantly different from M9 saline, and “c” stands for statistically significantly different from M9 saline and solutions labeled “b” (Student-Newman Keuls, p < 0.05). Data shown as mean ± s.e.m. (B) Chronic exposure to increasing concentrations of docetaxel increases the percentage of non-recovered worms following the electroshock. C.E. 0.0035 mM DTX vs. M9, X2 = 11.9656, p = 0.0005; C.E. 0.005 mM DTX vs. M9, X2 = 8.4176, p = 0.0037; C.E. 1 mM DTX vs. M9, X2 = 24.7284, p < 0.0001. N > 30 for each group. The horizontal reference line (0.01 mM Docetaxel Acute Exposure) indicates the mean value observed for acute exposure to 0.01 mM docetaxel [Fig 1]. **, p < 0.01; ***, p < 0.001; ****, p < 0.0001; all compared to M9.