A SNP-based capture and clustering workflow to assess donor-derived cell-free DNA in transplantation
Fig 5
Comparison of clustering-based estimation with direct genotype-based calculation.
Estimated dd-cfDNA ratios obtained using the clustering-based method with pre-transplant SNP data (orange:clustering_pre) and without pre-transplant SNP data (skyblue:clustering_wo) are compared to directly calculated values based on known donor and recipient genotypes (green:direct method). Each panel shows the time course of dd-cfDNA levels following kidney transplantation: (A) unrelated donor–recipient pairs, (B) sibling pairs, (C) parent–child pairs.