Mathematical modeling of the combined effects of thermal burn and local irradiation
Fig 2
M1 macrophage ratio to total macrophages and damage variable with varying prompt radiation doses.
The M1 ratio (panel A) denotes the total expression of M1 macrophages as a ratio of the total activated macrophage response such that 1 corresponds with 100% M1 activated macrophages and 0 corresponds with 0% M1 activated macrophages (100% M2 activated macrophages). Panel B shows the corresponding damage variable indicating damage resolution over time. Prolonged pro-inflammatory behavior has been widely evidenced to delay the wound healing process [48].