Elucidating the mechanistic association of xylene inducing non-small cell lung cancer through network toxicology and molecular docking analysis
Fig 5
Integrative validation of core gene expression patterns in lung cancer.
(A) Transcriptomic analysis of candidate genes in NSCLC tissues from the TCGA database, compared with adjacent normal tissues. The box plots show the expression levels. (B) Independent validation using the gene expression dataset GSE19188 from the GEO database. (C) Experimental validation by RT-qPCR in normal bronchial epithelial cells (Beas-2B) and lung cancer cell lines (A549, H1299, PC9). ns, p > 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001.