Pharmacokinetics of Dolutegravir, nucleoside analogues, and intracellular metabolites using plasma separation cards: A comparative analysis with traditional sampling methods in healthy volunteers
Fig 2
Geometric mean (95% confidence interval) nucleoside di-/triphosphate concentrations in HS-C and WM-DBS samples for (A) TFV-DPTAF, (B) FTC-TP, (C) TFV-DPTDF and (D) 3TC-TP during the 14-day drug intake cessation period.
HS-C is indicated with a solid black line (circles) and WM with a grey line (triangles). Metabolite concentrations are presented in fmol/sample (HS-C = 12 mm punch; WM-DBS = 6 mm punch). Detectable concentrations below the assay limit of quantification (HS-C = 250 fmol/sample, WM-DBS = 62.5 fmol/sample) are expressed as half LLQ values. Fig 2A displays HS-C data only, as all WM-DBS had undetectable TFV-DPTAF.