Population pharmacokinetics model of pyrazinamide to optimize tuberculosis treatment: An interethnic cohort study of diabetes mellitus effect on drug exposure
Fig 5
Probability of achieving maximum concentration (Cmax) of >60 mg/L for the simulated PZA dosing regimens according to the ethnicities and DM characteristics.
The WHO weight bands were represented by different colors line. Red line: < 40 kg weight band, blue line: 40-54 kg weight band, purple line: 55-70 kg weight band, and green line: > 70 kg weight band. The probability of target attainment (PTA) according to ethnicities is shown for (A) Indonesian; (B) Korean with each ethnic covariate of DM characteristics. DM: diabetes melltus, PZA: Pyrazinamide, Other patients: patients who aged < 60 years old with or without DM.