Population pharmacokinetics model of pyrazinamide to optimize tuberculosis treatment: An interethnic cohort study of diabetes mellitus effect on drug exposure
Fig 3
Relationships of DM and old DM with PK parameters of each ethnicity.
(A) Area under concentration of 0 to 24 hours between DM and non-DM patients in Indonesian ethnic. (B) Maximum concentration between DM and non-DM patients in Indonesian ethnic. (C) Apparent clearance between DM and non-DM patients in Indonesian ethnic. (D) Area under concentration of 0 to 24 hours between old DM and other patients in Korean ethnic. (E) Maximum concentration between old DM and other patients in Korean ethnic. (F) Apparent clearance between old DM and other patients in Korean ethnic. Box plot showing the interquartile range of each PK parameter. The groups are represented as follows: pink, DM in Indonesian, and old DM in Korean; blue, non-DM in Indonesian, and other patients in Korean. The straight line in the upper part of the box plot represents the t-test results. **** P < 0.001, ns: non-significant). DM: diabetes mellitus, old DM: ≥ 60 years old patients with DM, Other patients: patients who aged < 60 years old with or without DM, PZA: Pyrazinamide, PK: pharmacokinetics.