Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model
Fig 2
The biochemical markers in mice treated with CTX/PMB at three different CTX doses (low, medium, and high) and the control group (vehicle only) were quantified.
The parameters included A) creatinine, B) urea, C) alanine aminotransferase (ALT), D) alkaline phosphatase, E) aspartate aminotransferase (AST), F) total bilirubin, G) direct bilirubin, and H) indirect bilirubin. The dashed lines indicate the upper reference limits for each parameter. Statistical analysis was performed via one-way ANOVA; no significant differences were found among the groups.