Circadian rhythm disruption as a potential contributor to BPPV: Evidence from a young rat model vestibular effects of circadian disruption
Fig 2
Biochemical effects of constant light exposure on Otolin-1, melatonin, and 25(OH)D levels in rats.
(A) Serum Otolin-1 levels were significantly higher in the constant light (CL) group compared to controls, indicating a potential biomarker of otoconial disturbance (**p:0.0075; n:12-14). (B) Similarly, cochlear Otolin-1 concentrations were elevated in the CL group, supporting the possibility of inner ear structural changes under circadian disruption (*p:0.0129; n:9). (C) Melatonin levels, measured at the onset of the passive period, were significantly reduced in the CL group, confirming suppression of pineal activity and disruption of the circadian rhythm (*p:0.0113; n:12-14). (D) Serum vitamin D concentrations were markedly lower in CL-exposed rats, suggesting impaired synthesis or altered metabolism due to lack of dark-phase signaling (**p:0.0094; n:7). All data are expressed as mean ± SEM.