An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge
Fig 2
LA-2 LALAPG is deficient in complement deposition in vitro.
(A) Binding (MFI) of LA-2 IgG and LA-2 LALAPG to recombinant OspA. The asterisks indicate a significant difference between groups by Welch’s t-test (**P < 0.01). Quantification and comparison of human complement C3 deposition between LA-2 and LA-2 LALAPG in the context of OspA. The asterisk indicates a significant difference between groups by Welch’s t-test, where *P < 0.05. (C) Dose response of complement C3 deposition of LA-2 and LA-2 LALAPG in the context of OspA.