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Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles

Fig 9

Summary of bioanalytical tools used for mispairing screening and characterization.

ProtA – protein A purified samples; Clarif – Clarified samples. Color gradient corresponds to peak areas obtained in SEC-MS analysis: red gradient – LC’s, half-mabs and full mAbs mispaired species; green gradient – full mAb correct form. * No data available for clarified sample of clone H, as no MS signal was obtained.

Fig 9

doi: https://doi.org/10.1371/journal.pone.0336791.g009