Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles
Fig 5
Type and distribution of tsAb complete species from distinct samples (A, B, C, D, F, G, H, I and J) analyzed by SEC-MS.
Percentage of complete mAb species calculated for (A) Protein A purified and (B) clarified samples. H1L1/H2L2 corresponds to correct form (blue bars) and remaining mispaired species are depicted in other colors. Threshold line at 80% of complete mAb species. *No data available for clarified sample of clone H, as no MS signal was obtained.