Improved CRISPR/Cas9 off-target prediction with DNABERT and epigenetic features
Fig 2
Performance comparison of all models on the Lazzarotto et al. (2020) GUIDE-seq dataset.
Boxplots show the distribution of (A) F1-score, (B) MCC, (C) ROC-AUC, and (D) PR-AUC scores from the 14-fold cross-validation experiments. The central line in each box indicates the median, the box represents the interquartile range (IQR), and the whiskers extend to 1.5 times the IQR. Dots beyond the whiskers are outliers. Statistical significance between model pairs was determined using the two-sided Wilcoxon signed-rank test with Benjamini-Hochberg correction. Significance levels are denoted as follows: ns: p > 0.05, *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001, ****: p ≤ 0.0001.