Identification of potential biomarkers and therapeutic targets for underactive bladder based on bioinformatics analysis and experimental validation
Fig 4
Hub gene identification, and GEO dataset validation.
(A) The top 10 hub genes identified in the PPI network through the Cytohubba plugin, with the color intensity of the genes corresponding to their score values. (B) The functional clustering module extracted from the PPI network through MCODE contain 12 genes, with the color intensity of the genes corresponding to their degree values. (C) The mRNA expression of 10 hub genes was determined from the GSE28242 validation dataset, six genes have significant expression differences. (D) Diagnostic value of 10 hub genes analyzed with ROC curves. AUC, area under the ROC curve. ns, no significant difference.