Identification of potential biomarkers and therapeutic targets for underactive bladder based on bioinformatics analysis and experimental validation
Fig 2
Identification of differentially expressed genes (DEGs).
(A-B) Volcano plot of DEGs between datasets GSE122060 and GSE100219. Red dots: upregulated, blue dots: downregulated. Parameter settings are |log2FC| > 1 and p-value (FDR correction) < 0.05. (C-D) Heatmap of DEGs in datasets GSE122060 and GSE100219. Rows represent genes; columns represent samples. Expression values were row-normalized (Z-score) based on log2(TPM + 1) data. Hierarchical clustering (Euclidean distance, average linkage) was applied to genes. (E) Venn diagram of upregulated and downregulated genes in two datasets.