A framework to enhance the signal-to-noise ratio for quantitative fluorescence microscopy
Fig 1
Illustrating the signal-to-noise ratio model of an EMCCD camera.
(A) The path of photons (green) emitted by the light source, arriving at the camera sensor, get converted into electrons (-) that are amplified and converted into pixel intensity by the Analogue-to-Digital converter (ADC). (B) The raw intensity at high and low signal to noise ratios showing the signal of interest relative to the noise.